Kalapini

Family • Asteraceaew - Pluchea indica (Linn.) Less. - MARSH FLEABANE - Luan xi

Scientific names

Baccharis indica Linn.
Conyza corymbosa Roxb.
Conyza foliolosa Wall. ex DC.
Conyza indica var. indica
Pluchea indica (Linn.) Less.
Kuo bao ju (Chin.)

Common names

Banig-banig (Sul.)
Bauing-bauing (Sul.)
Kalapini (Tag.)
Lagunding-late (Sbl., Tag.)
Tulo-lalaki (P. Bis.)
Indian camphorweed (Engl.)
Indian pulchea (Engl.)
Marsh fleabane (Engl.)
Luan yi (Chin.)

Other vernacular names

CAMBODIA: Pros anlok.
CHINA: Ge za shu
INDONESIA: Beluntas (Indonesian), luntas (Javanese), baruntas (Sundanese).
LAOS: Nat luat.
MALAYSIA: Beluntas, Beluntas paya.
PAPUA NEW GUINEA: A’apu.
THAILAND: Khlu, Nuat ngua, naat wua.
VIETNAM: C[us]c t[aaf]n, l[as] l[uws]c.

Botany
Kalapini is an erect, much-branched shrub, 1 to 2 meters in height. Leaves are oblong-ovate to oblong-elliptic and 1.5 to 4 centimeters long, with pointed or blunt tip, wedge-shaped base, and slightly and irregularly toothed margins. Inflorescence is a compound, terminal, slightly hairy corymb 5 to 11 centimeters long. Numerous heads are about 5 millimeters long. Involucral bracts are ovate, with the inner ones gradually longer. Flowers are numerous, and pink-purple or lilac. Achenes are minute and ribbed; the pappus is white, scanty, and spreading.

Kalapini

Distribution
– From northern Luzon to Mindanao, along the seashore and tidal streams within the influence of salt or brackish water.
– Also occurs in India to China and Malaysia.

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Constituents
– Yields an essential oil.

Properties
– Astringent, antipyretic.
– Studies suggest anti-inflammatory, antimicrobial, gastroprotective, antivenom, antioxidant properties.

Additional Sources and Suggested Readings

(1) In vitro Antimicrobial Activity of Pluchea indica Aqueous Extract: The Potential for Urinary Tract Infection Treatment / ittiwet, C. / J. Pharmacol. Toxicol., 4: 87-90, 2009 / DOI: 10.3923/jpt.2009.87.90

(2) Studies on the effects of Pluchea indica less root extract on gastroduodenal ulcer models in rats and guineapigs / Siddhartha Pal, A. K. Nag Chaudhuri / Phytotherapy Research, Vol 3, Issue 4, pages 156–158, 1989 / DOI: 10.1002/ptr.2650030410

(3) Antioxidant activity of the methanol fraction of Pluchea indica root extract / T Sen, A K Dhara, et al / Phytotherapy Research, Volume 16, Issue 4, pages 331–335, June 2002 / DOI: 10.1002/ptr.892

(4) Studies on the neuropharmacological aspects of Pluchea indica root extract / T Sen, A K Nag Chaudhuri / Phytotherapy Research, Volume 6, Issue 4, pages 175–179, July/August 1992 / DOI: 10.1002/ptr.2650060402

(5) Pluchea indica / Vernacular names / GLOBinMED

(6) Studies on the Methanolic Fraction of Pluchea indica on Croton Oil-induced Mouse Ear Oedema and Lipid Peroxidation / Pharmacy and Pharmacology Communications, Volume 2, Issue 9, pages 433–435, September 1996 / DOI: 10.1111/j.2042-7158.1996.tb00650.x

(7) Antioxidant and antiacetylcholinesterase activities of Pluchea indica Less. / Noridayu, A. R., Hii, Y. F., Faridah, A., Khozirah, S. and Lajis, N. / International Food Research Journal 18(3): 925-929 (2011)

(8) IN VIVO BIO-ACTIVITY OF PITC-II DERIVATIVE (PART II) / Tapan Kumar Chatterjee et al / INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY, 2012, 2(2)

(9) MOSQUITOCIDAL ACTIVITIES OF ISOLATED COMPOUNDS FROM THE ESSENTIAL OIL OF PULCHEA INDICA L. (ASTERACEAE) AGAINST FIVE MEDICALLY IMPORTANT HUMAN VECTOR MOSQUITOES (DIPTERA : CULICIDAE) / Kuppusamy Elumalai / Instasci journal of chemistry 01/2013; 3(1)

(10) Crude aqueous extracts of Pluchea indica (L.) Less. inhibit proliferation and migration of cancer cells through induction of p53-dependent cell death / Jonathan J Cho, Chung-Lung Cho*, Chiu-Li Kao, Chien-Ming Chen, Chao-Neng Tseng, Ya-Zhe Lee, Li-Jen Liao and Yi-Ren Hong / BMC Complementary and Alternative Medicine 2012, 12:265 doi:10.1186/1472-6882-12-265

(11) Corrosion Inhibition of Low Carbon Steel by Pluchea Indica Less in 3.5% NaCL Solution / R. I. Pramana, R. Kusumastuti, Johny Wahyuadi Soedarsono, A. Rustandi / Advanced Materials Research (Volumes 785 – 786)

(12) The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line. / Kasmuri, Abdul Razak and Bakhtiar, Muhammad Taher and Suriyah, Wastuti / 26th Scientific Meeting of Malaysian Society of Pharmacology & Physiology, 18-20 may 2012, Equatorial Hotel, Penang.

(13) Identification of α-glucosidase inhibitors from the leaves of Pluchea indica (L.) Less., a traditional Indonesian herb: promotion of natural product use / Kawabata, Jun; Ines Septi, Arsiningtyas; Maria D.P.T., Gunawan-Puteri; Eisuke, Kato / http://dx.doi.org/10.6084/m9.figshare.987071

(14) Hepatoprotective Effects of Pluchea indica (L.) Less. Aqueous Extract against Thioacetamide-induced Liver Fibrosis in Mice / Wu, Li-chuan / 2009 / Thesis and Dissertation

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Parts used
Roots, leaves.

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Uses 
Folkloric
– In India, roots and leaves used medicinally as astringents and antipyretics.
– In Indo-China, decoction of roots used in fevers as diaphoretic; infusion of leaves for lumbago.
– In South-East Asia and Thailand, leaves are used as nerve tonic and for treating inflammation.
– Decoction of bark used for hemorrhoids.

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Study Findings
• Anti-Inflammatory: Study of methanolic fraction of chloroform extract of defatted Pluchea indica roots showed significant inhibitory activity against carrageenin-, histamine-, serotonin-, hyaluronidase- and sodium urate-induced pedal inflammation. Results establish the extract efficacy in exudative, proliferative and chronic stages of inflammation.
• Phenolic Content: Study showed a significant difference in the total phenolic content among different parts of the tested plant. Leaves contained the highest phenolic compounds, followed by the stems, and lower in the flowers.
• Antimicrobial: An aqueous extract was tested against both gram positive and gram negative bacteria. Results showed zone of inhibition against E coli and K pneumonia. Result showed a possibility of using P. indica as an alternative therapy in the treatment of urinary tract infections.
• Gastroprotective: The methanolic fraction of P. indica root extract was found to possess significant antiulcer activity in different experimental animal models. It showed significant protective actions in acetylsalicylic acid, serotonin and indomethacin-induced gastric lesions in experimental rats.
• Antioxidant / Root: Study on P. indica root extract showed significant anti-inflammatory activity against glucose oxidase-induced paw oedema, inhibition of hydroxyl radical and superoxide generation, CCl4-induced lipid peroxidation and dioxygenase activity.
• Snake Venom Neutralization: Studies on antidotes for snake envenomation has shown Pluchea indica as one of several herbal plants that possess moderate neutralizing activity against snake venom.
• Viper and Cobra Venom Neutralization: Study reports the neutralization of viper and cobra venom by b-sitosterol and stigmasterol isolated from the root extract of P. indica. Study suggests beta-sitosterol and stigmasterol may play an important role, along with antiserum, in neutralizing snake venom-induced actions.
• CNS Depressant: Study of root extract showed a potent CNS depressant action with alteration of behaviour pattern, reduction in spontaneous motility, prolongation of pentobarbitone-induced sleep, suppression of aggressive behaviour patters and conditioned avoidance response.
• Anti-Inflammatory / Antioxidant: : Study assessed the inhibitory effect of P. indica on croton oil-induced mouse ear edema, lipid hydroperoxide, and in vitro lipid peroxidation. Results showed the methanolic fraction of root extract possessed significant anti-inflammatory and antioxidant activity.
• Antioxidant / Anticholinesterase: A methanolic extract of stems was found to have both anti-AChe properties and moderate antioxidant activity. Anticholinesterase inhibitors are one of the treatment options in Alzheimer’s disease.
• Antioxidant / Herbal Tea: Study showed a hot water extract of P. indica leaves is a source of antioxidants and inhibitors of NO and PGE2 production and can be used as dietary supplement with health promoting effect.
• PITC II / Anticancer: PITC-2 is a new thiophene compound obtained from P. indica cultured plant. Synthesized monoamine derivatives showed in in-vitro studies to have anticancer and cytotoxic effects against human leukemic cell lines.
• Mosquitocidal / Essential Oil: Study evaluated the mosquitocidal activity of essential oil of Pluchea indica against larvae and eggs of Aedes aegypti, A. albopictus, Anapheles stephensi, A. subpictus and Culex quinquefasciatus. Results showed various degrees of ovicidal activity that increased with concentration. Results lead the path for exploration of P. indica for the eradication of selected medically important human vector mosquitoes.
• Anti-Cancer / Leaf and Root: Crude aqueous extracts of P. indica leaf and root suppressed proliferation, viability, and migration of GBM8401 and HeLa cells. In vitro anti-cancer effects of crude leaf and root extract show potential as a new anti-cancer agent.
• Corrosion Inhibition / Leaf Extract: Study investigated the inhibition of low carbon steel in 3.5% NaCl of Pluchea indica leaves extract. Results showed the extract to behave as a mixed type corrosion inhibitor.
• Anti-Diabetic / Increased Insulin Release: A previous study showed a crude extract to lower blood glucose in hypoglycemic test on normal rats. Study of glibenclamide-treated, hexane, dichlormethane and water extract treated groups showed ß-cell effect with increase insulin release.
• α-Glucosidase Inhibition / Increased Insulin Release: Pluchea indica leaf extracts have inhibitory activity against intestinal maltase. Study suggests a potential for P. indica as functional food and medical supplement for the treatment and prevention of diabetes.
• Hepatoprotective / Thioacetamide-Induced Liver Fibrosis: Study evaluated an aqueous extract of root of Pluchea indica on a TAA-induced liver fibrosis mouse model. Results showed an anti-fibrotic effect.

Availability
Wild-crafted.