Family • Podocarpaceae - Podocarpus macrophyllus (Thunb.) D. Don - BUDDHIST PINE
|Buddha pine (Engl.)|
|Buddhist pine (Engl.)|
|Japanese yew pine (Engl.)|
Additional Sources and Suggested Readings
(1) Antimicrobial activity of South African Podocarpus species / H S Abdillahi et al / Journal of Ethnopharmacology / Volume 119, Issue 1, 2 September 2008, Pages 191-194 / doi:10.1016/j.jep.2008.06.023
(2) Sustained mammary gland-directed, ponasterone A-inducible expression in transgenic mice / Chris Albanese et al / The FASEB Journal. 2000;14:877-884
(3) Studies on Bisflavones in the Leaves of Podocarpus macrophylla and P. nagi / Miura Hiroshi et al / Chemical & pharmaceutical bulletin • 17(1) pp.150-154 19690125
Evergreen shrub or tree that may grow 20 to 30 feet high. Branches are numerous, crowded and upright. Leaves are narrow-linear to lanceolate, stiff with an acute tip and obtuse base. Blade is dark green above and pale green below, with entire margins. Male and female cones are in separate plants. Seed is globose-ovoid and borne in a fleshy violet receptacle.
Introduced to the Philippines after WWII.
Common garden cultivation.
Constituents and Characteristics
•Study yielded a new biflavonoid, 2,3-dihydro-4′,4”’-di-O-methylamentoflavone and five known compounds (catechin, quercetin, 2,3-dihydrosciadopitysin, sciadopitysin, and isoginkgetin.
• From the leaves, study yielded hinokiflavone, neocryptomerin, sciadopitysin, podocarpusflavone A and podocarpusflavone B.
No reported folkloric medicinal use in the Philippines.
• Anti–pigmentation: Study yielded a new biflavonoid, 2,3-dihydro-4′,4”’-di-O-methylamentoflavone and five known compounds (catechin, quercetin, 2,3-dihydrosciadopitysin, sciadopitysin, and isoginkgetin. The new biflavonoid was the most active component in inhibiting pigmentation through inhibition of transcription of the genes encoding TRP2.
• Antimicrobial / Antifungal: A study of South African Podocarpus species showed all four tested species exhibited antimicrobial activity, the highest against K pneumonia. All species exhibited strong antifungal activity.
• Ponasterone / Mammary Gland Disease: Sustained mammary gland-directed, ponasterone A-inducible expression in transgenic mice. The transgenic model with both tightly regulated and homogenoeous transgene expression has broad practical applicability for genetic analysis of mammary gland disease.
• Cytotocxic: Study yielded 14 new bisnor- and norditerpene dilactones, makilactones E-R and 13 known bisnor- and norditerpenoids from the methanolic extract of the root and bark of Podocarpus macrophyllus. Many of the compounds showed potent cytotoxic activities against P388 murine leukemia cells.